Evaluation of sustained release matrix tablets of cilostazol

This wigs specials nucleus has our conquer offers. Int J Pharm Sci Res ;2 Drug Dev Ind Pharm ; All the chemicals were of analytical grade. Preparation and in vitro evaluation. The development of oral controlled release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract.

As there is a very vast scope for the research in the field of pure and Medical Sciences, various free publications are categorized into open access medical journals and open access clinical journals. Morphology and surface properties of the tablets were found to be affected by the polymer concentration.

No significant change in the appearance of characteristic peaks of pure drug spectra was observed fig. The release profile of salbutamol sulphate was monitored up to 8 hours.

Hydroxy polymer for sustained release, such as methyl cellulose can secure a longer elution time by forming a matrix matrix for preventing the rapid elution of the pharmacologically active ingredient in the tablet.

However, in the case of a sustained-release tablet containing a pharmacologically active ingredient show swelling phenomenon of the tablet during dissolution.

Most of the open access journal articles can be cited with proper reference, which boosts the prospects of research. Acebrophylline is a xanthine derivative with potent bronchodilator, mucosecretolytic, and anti-inflammatory property.

Study of physical interaction between drug and polymer: This process assures considerable impact factor for the journal and reputation to the authors that add value to their Academic Performance Index API Score. Curr Drug Deliv ;2 1: This indicates that the drug is compatible with the polymers used in the investigation.

Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been evaluated. The present invention is characterized by containing a solubilizer suitable for the case of poorly soluble drugs is especially subject suffering emission, and an additional disintegrating agent for a sufficient initial release.

As a result, the importance of open access journals is growing significantly. In this case, the matrix of sustained-release polymer for the matrix if not solid, some damage can occur a phenomenon that the tablet disintegrates, which leads to rapid drug release can be caused to the patient for headache and flushing.

Open Access Journals

Int J Appl Pharm ;9: This system provides easy access to networks of scientific journals. World J Pharm Res ;4: Case II generally refers to the erosion of the polymeric chain and anomalous transport non-Fickian refers to a combination of both diffusion and erosion controlled-drug release The present invention been made in view of the above problems, while prior art have the advantage of a matrix structure it is possible to, even after the collapse of matrix structure inhibiting the rapid release of the drug, sikimyeo completely solubilize the drug of suffering availability, the initial release rate It is to be the object of the present invention to provide a new and improved drugs for controlled release composition.

Indian J Pharm Biol Res ;3 1: The absorption of rabeprazole occurs rapidly as soon as tablet leaves the stomach. Mathematical models for drug release characterization: Combining Eudragit with gum Copal and gum Damar sustained the drug release for more than 12 h.

Compared to conventional immediate release rapid release in the sustained-release preparation controlled release preparations may be due to the sustained release of drug for a period of time in the body, maintain the effective blood concentration of drug for long periods of time.

This results do not appear to make a rapid release of the drug after ingestion difficult to expect the initial pharmacological effect. Further, there in the following description is described in many specific details such as concrete components, which is that the present invention without the need to be such particulars as provided to assist the overall understanding of the invention can be carried out is generally in the art who has the knowledge of it it would be obvious.

Example Test Example 1: Specifically, carbonyl dimmer on the acidic conditions present in drug release by a sol state is maintained by the sustained release polymer for, in the alkaline conditions of the small intestine by the presence in the hydrogel state and controls the release of the drug.

Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport.

The overall objective of this study was to develop an oral sustained release metformin hydrochloride tablet by using hydrophilic Eudragit RSPO alone or its combination with hydrophobic natural polymers Gum copal and gum damar as rate controlling factor.

Once daily sustained release matrix tablets of nicorandinal formulation in vitro evaluation.

Avis de Recherche

AAPS Pharm Sci Tech ; 4: [5] Mohammed AD, James. The title of the thesis is FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ACECLOFENAC AND ITS PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES IN ANIMAL MODEL. Aceclofenac is a synthetic non- steroidal anti-inflammatory drug (NSAID) used in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

It. compliance, a sustained release formulation of tramadol is developed5. The main objective of the present work was to develop sustained release matrix tablets of water soluble Tramadol hydrochloride using different polymers viz.

Hydroxy propyl methyl cellulose (HPMC) and natural gums like Karaya gum (KG) and Carrageenan (CG). The rate of drug release was found to be inversely related to the amount of methocel KM CR present in the matrix structure, i.e. the drug release increased with decrease in the polymer content of the matrix tablet (Fig.

3). The release kinetics data has been mentioned in the Table 2. ter-soluble drugs, the development of sustained release coated granules has a unique advantage of lessening the chance of dose dumping which is a major problem when highly water-soluble drug is formulated as matrix tablets.

Most of the researchers have worked on matrix tablets and multilayered matrix tablets. In the present study, a. Sustained release, sustained action, prolonged action, controlled release, extended action, timed release and depot dosage form are term used to identify drug delivery system that are designed to achieve prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose.

Evaluation of sustained release matrix tablets of cilostazol
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